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Table 2 Details of studies comparing PRP and corticosteroid injections

From: The effects of regenerative injection therapy compared to corticosteroids for the treatment of lateral Epicondylitis: a systematic review and meta-analysis

Reference/ PEDro score
Sackett’s Evidence Level
ParticipantsMethodsOutcome MeasuresResults
Gosens et al. (2011),
PEDro = 9
n = 100 participants
PRP group:51,
Age: 46.8 ± 8.5 yrs.
23 males, 28 females
CS group: 49
Age: 47.3 ± 7.8 yrs.
23 males, 26 females
• Participants received CS injection (one mL with bupivacaine hydrochloride 0.5%) or PRP injection (three mL buffered with 8.4% sodium bicarbonate and bupivacaine hydrochloride 0.5%)
• Injections provided in common extensor tendon through a peppering needling technique.
• Outcomes assessed at baseline and at 1 month, 2 months, 3 months, 6 months, 1 year and 2 years after the injection.
• VAS
• DASH
• CS group had lower pain and improved on DASH scores at 1 month.
• No between group changes at 2 months
• PRP group had better outcomes at all other assessments.
Gautam et al. (2015)
PEDro = 6
n = 30 participants
PRP group = 15
CS group = 15
No information provided about age or sex distribution
• Injection delivered using peppering technique at most tender point over lateral epicondyle of humerus
• Participants received two ml of PRP or 40 mg/ml of methylprednisolone.
• Outcomes assessed before and at 2 weeks, 6 weeks, 3 months, and 6 months after injection.
• USG was performed before and after injection at three and 6 months
• VAS,
• DASH
• Oxford Elbow score
• Modified Mayo Clinic performance index for elbow,
• Hand grip strength
• All outcome measures improved significantly from pre-injection to 6-month retention in both groups.
• CS group had greater changes at two- and 6-weeks post-injection. However, the scores of CS group peaked at 3 months and deteriorated at 6 months
• No between groups differences present at 3 months
• In the CS group, patients with reduced thickness of tendon increased from two to 12.
• PRP group had better within group changes in outcomes at 6 months (p < 0.05).
Yadav et al. (2015)
PEDro = 5
n = 60 participants
PRP group: 30
Mean Age: 36.6 yrs.
10 males, 20 females
CS group: 30
Mean age: 36.6 yrs.
7 males, 23 females
• Both groups received injection into common extensor origin.
• PRP: single injection (one ml), with absolute platelet count of 1 million platelets/ mm3
• CS: single injection of corticosteroid (methylprednisolone, 40 mg in one ml)
• Data collected at baseline and 15 days, one and 3 months after injection.
• VAS,
• grip strength
• qDASH
• CS group had statistically significant and better improvement than PRP group at 15 days and at the 1 month follow assessment.
• At end of 3 months, VAS, qDASH and grip strength was significantly better in PRP group (p < .0001).
Krogh et al. (2013),
PEDro = 8
n = 60 participants:
20 saline,
Age: 44.7 ± 7.9 yrs.
9 males, 11 females
20 PRP,
Age: 47.6 ± 7.1 yrs.
9 males, 11 females
20 CS
Age: 45.4 ± 8.0 yrs.
11 males, 9 females
• Injections provided using an ultrasound-guided, antiseptic peppering technique in the common extensor origin.
• The three ml consisted of one ml of triamcinolone (40 mg/ml) and two ml of lidocaine (CS group), three ml of saline or three ml of PRP.
• All participants prescribed a standard stretching and training program.
• Outcomes assessed at baseline, and at one and 3 months after injection.
• PRTEE
• USG changes in tendon thickness
• Color Doppler activity
• CS group had maximum reduction in pain and DASH scores at 1 month. Assessment.
• All groups improved at 3 months assessment period with no between group differences.
• Maximum reduction in tendon thickness and color doppler outcomes in the CS group at 3 months
PRP group had greater changes in tendon thickness and Doppler outcomes compared to saline.
  1. PEDro Physiotherapy Evidence Database Research Organisation, PRP Platelet rich plasma, CS Corticosteroid, ECRB Extensor Carpi Radialis Brevis, VAS Visual Analog Scale, DASH Disabilities of the Arm, Shoulder and Hand, PRTEE Patient Rated Tennis Elbow Evaluation, qDASH Quick form of DASH