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Breast edema, from diagnosis to treatment: state of the art



Breast edema can arise from different etiologies; however, it is mostly seen after breast conserving surgery and/or radiotherapy. Combining breast conserving surgery and radiotherapy can cause damage to the lymphatic system and reactions to surrounding tissues, which can lead to breast edema; hereby, the breast size can increase by more than one cup size. Swelling of the breast is not the only criterion associated with breast edema. Other common criteria found in literature are peau d’orange, heaviness of the breast, skin thickening, breast pain, redness of the skin, hyperpigmented skin pores and a positive pitting sign. Despite the benefits of breast conserving surgery, breast edema can be uncomfortable, and can negatively influence quality of life in suffering patients. In contrast to lymphedema of the arm, which is well known in clinical practice and in research, breast edema is often underestimated and far less explored in literature. Currently, many aspects still need to be reviewed.

Purpose and importance to practice

This masterclass aims at providing the state of the art of breast edema for all health care workers and researchers involved in the treatment and monitoring of breast cancer patients. It includes current and future perspectives on its diagnosis, longitudinal course and treatment. Furthermore, recommendations for clinical practice and future research are discussed.

Clinical implications

It is recommended to closely monitor those patients in whom breast edema symptoms do not decline within 6 months after termination of radiotherapy and provide them with the appropriate therapy. Since evidence concerning the treatment of breast edema is currently lacking, we recommend the complex decongestive therapy (CDT) to the utmost extent, by analogy with the lymphedema treatment of the extremities. This treatment involves skin care, exercise therapy and compression. Additionally, all patients should be informed about the normal course of breast edema development.

Future research priorities

A consensus should be reached among clinicians and researchers concerning the definition, assessment methods and best treatment of breast edema. Furthermore, high quality studies are necessary to prove the effectiveness of the CDT for breast edema.


Breast cancer is the most common malignancy in women in the Western World [1]. Over the years, breast cancer surgery has evolved to more conservative procedures, as for example breast-conserving surgery (BCS). In most cases this procedure involves radiotherapy, in addition to the local excision. BCS followed by radiotherapy is a safe and effective procedure to treat patients with early stage breast cancer [2]. However, some patients will be troubled by breast edema in the operated and irradiated breast. Breast edema is far less explored in literature compared to lymphedema of the arm. Although, it is gaining relevance due to the increase in patients receiving BCS together with adjuvant radiotherapy. Both aspects of this treatment can cause breast edema. The surgery itself can cause damage to the lymphatic system, which can lead to a compromised transport capacity not only in the arm, but also in the breast. However, the main contributing factor is radiotherapy, which causes various tissue reactions, including edema. Furthermore, venous and lymphatic obstruction could take part in de development of breast edema [3]. In breast edema patients, the breast size can increase by more than one cup size [4]. However, swelling is not the only criterion that is associated with breast edema. Besides an increased volume of the breast [5,6,7,8,9,10], other common criteria found in literature are peau d’orange [4,5,6, 8,9,10], heaviness of the breast [5, 8, 9], redness of the skin [5, 6, 10], breast pain [4,5,6, 9, 10], skin thickening [6, 11], hyperpigmented skin pores [10] and a positive pitting sign [6] (see Fig. 1). Nevertheless, many studies do not describe a definition for breast edema, making it a difficult topic to study. Clinically, a difference between breast edema and lymphedema of the extremities can be observed. Breast edema is characterized by skin changes, hardness of the breast and pain, but can also be present without visible swelling, whilst the main property of lymphedema of the extremities is swelling. Irradiation causes hardening of the fat tissue. Since a female breast contains lots of adipose tissue, it is likely to undergo those changes post-radiation [12].

Fig. 1

Examples of women suffering from breast edema. The increased volume (including the pitting) is seen on all pictures. In the lower left picture an irregular shape of the breast is seen and the lower right is an example of peau d’orange

Besides surgery and radiotherapy for breast cancer, breast edema can have other etiologies, which are however less common: inflammatory breast carcinoma, metastasis, breast lymphoma, mastitis, fat necrosis, trauma, congestive heart failure etcetera [3]. Therefore, a patient’s clinical history and examination is very important to set an accurate diagnosis and to give appropriate advice or treatment. In contradiction to the natural course of breast edema provoked by BCS and radiotherapy; breast edema from other etiologies often has a chronic stage [3].

Delay et al. classified breast edema into different stages [9]. Stage 1 is characterized by thickening of the skin, while the breast volume remains unchanged. In stage 2, breast edema presents as a visible edema which can lead to asymmetry between both breasts. In patients with severe breast edema, the volume of the operated and irradiated breast can sometimes increase up to 300 ml. Stage 2 is further characterized by dilated skin pores, which is called peau d’orange, heaviness, pain and pitting edema on the affected breast. Stage 3 of breast edema is similar to stage 2, but in this stage the pain is more extensive [9]. Wratten et al. describes 2 components of breast edema. Firstly, generalized enlargement or swelling of the breast tissue itself may occur, which is referred to as parenchymal breast edema. Secondly, there may be evidence of edematous changes in the epidermis and dermis, which is referred to as cutaneous breast edema. Although cutaneous breast edema may occur by itself, in many instances, there will be a combination of both components [11]. Besides the absence of a clear definition for breast edema, there is no standardized method to assess breast edema neither. The most common method found in literature is the physical examination [4, 6, 7, 13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29]. Other assessment methods are mammography [16, 30], ultrasound [6, 11, 16], MRI [31], the tissue dielectric constant (TDC) technique using the MoistureMeterD [32] or questionnaires [5, 23, 26, 33, 34]. Based on a systematic review of the literature, the overall incidence of breast edema following BCS and radiotherapy ranges between 0 and 90.4% [35]. This range includes all kinds of assessment methods and definitions of breast edema and is therefore very broad. Furthermore, evidence on the treatment of breast edema is lacking as well. Therefore, in this paper we provide recommendations based on the current knowledge of lymphedema treatment of the limbs, namely the complex decongestive therapy (CDT). This masterclass is established based on systematic review of the current scientific literature using Pubmed, Embase, Web of Science and Cochrane clinical trials and original prospective research, in the context of a doctoral dissertation. In addition, it is based on clinical experience. It aims at providing the state of the art of breast edema for all health care workers and researchers involved in the treatment and monitoring of breast cancer patients. It includes current and future perspectives on its diagnosis, longitudinal course and treatment. It involves recommendations for clinical practice and for future research.

Management of breast edema


In 2014 a rigorous systematic review was published on the topic of breast edema concluding that a standardized protocol to assess breast edema as well as a clear definition for diagnosis was lacking [35]. A physical examination is the most commonly used method found in literature to assess breast edema in which symptoms of breast edema are evaluated by means of inspection, palpation and anamnesis [4, 6, 15, 16, 19,20,21,22,23, 25, 26, 29]. Additionally, clinical pictures of the breasts could be taken in order to assess the evolution more accurately [7, 17, 28]. Furthermore, several imaging techniques are described in literature, for instance high-frequency ultrasound (HFUS). Clinical signs of breast edema on HFUS are thickening of the skin over 2 mm with increased echogenicity, disturbance or poor visibility of the deeper echogenic line and interstitial fluid accumulation [6, 11, 36]. An MRI allows to detect fluid-containing formations such as parenchymal and cutaneous breast edema, which are visible as white areas [31]. On mammography, parenchymal breast edema is seen as trabecular thickening and cutaneous breast edema as skin thickening [30]. Another technique that could provide information on breast edema is TDC, measured with the MoistureMeterD. This device can measure local tissue water to the depth of 2.5 mm. A TDC ratio between the affected and healthy breast, equal to or greater than 1.40, is seen as breast edema [37]. As a result of the different definitions and assessment methods used; breast edema incidence range is very broad [35]. With this conclusion in mind, the Breast Edema Questionnaire (BrEQ) was developed [34]. This Dutch questionnaire is the first, with evidence of validity and reliability, for assessing breast edema in breast cancer patients. Furthermore, the synthesis of symptoms listed in the BrEQ, can be a catalyst to develop a standard definition for breast edema. In the first part of the questionnaire, symptoms of breast edema are scored on a scale from 0 to 10: pain, heaviness, swelling, tensed skin, redness, pitting sign, enlarged skin pores and hardness. Taking into account the International Classification of Functioning, Disability and Health (ICF), several activity limitations and participation restrictions are scored from 0 to 10 in part 2. Clinimetric properties of the BrEQ were tested in a group of breast cancer patients who underwent BCS and radiotherapy. An overview of these clinimetric properties is presented in Table 1. It shows that the BrEQ is a reliable and valid Dutch questionnaire for assessing breast edema. Moreover, a score cut-off point of 8.5 is determined. This score discriminates between patients who have breast edema and those who have not [34]. In conclusion, the BrEQ is a useful tool to assess and diagnose breast edema in clinical practice and to detect its impact on daily functioning. An English translation of the BrEQ is provided in the Appendix (see Additional file 1).

Table 1 Clinimetric properties of the Breast Edema Questionnaire (BrEQ)

Longitudinal course

Several studies investigated the natural course of breast edema over time and demonstrated similar findings [5, 15, 23, 29, 37, 38]. In Table 2 an overview of the available literature in which all assessment methods and all definitions of breast edema are included, is presented. In female breast cancer patients who underwent BCS in combination with radiotherapy, a peak in prevalence was observed after termination of radiotherapy. Afterwards, a gradual spontaneous decline can be expected in the following months [40].

Table 2 Time course of breast edema in scientific literature

The degree of breast edema has about the same timeline as its prevalence. Figure 2 shows the BrEQ-scores on 80 up until 12 months after radiotherapy. Few studies investigated its degree longitudinally. Wratten et al. described the time course of cutaneous breast edema based on the increase in epidermal thickness, measured with US. In most breast cancer patients who underwent BCS and radiotherapy, epidermal thickness usually peaks at 4 to 6 months post-treatment and in most instances show signs of returning to baseline, 12 months post-treatment. The course of parenchymal breast edema has about the same timeline [11].

Fig. 2

BrEQ-scores on a total score of 80 on different time points

In many patients, breast edema is already present prior to radiotherapy. This can be explained by several factors. First, the fact that BCS itself causes breast edema, due to damage to the lymphatic system. This compromises lymphatic transport and could therefore cause breast edema [35]. Second, after BCS, breast edema could be mistaken for typical post-operative complaints such as pain, swelling, tensed skin, etcetera, which aren’t in fact directly associated with breast edema.

A spontaneous decline in breast edema symptoms within 6 months after termination of radiotherapy, can be referred to as transient breast edema. In case the breast symptoms show no signs of return more than 6 months post-radiation, it is called persistent breast edema. We strongly advise patients and health care workers involved in the treatment and after-treatment of breast cancer patients to closely monitor breast complaints after radiotherapy. In cases of mild breast symptoms and/or transient breast edema, treatment is not necessary. Patients with persistent breast edema and/or patients in who the breast complaints are very pronounced and bothersome are recommended to get appropriate treatment.

Conservative treatment of breast edema

The current evidence based treatment for lymphedema of all sorts is the CDT, which is generally accepted as consensus treatment [41, 42]. However, some aspects of the CDT, namely the manual lymphatic drainage (MLD) are up for debate [43,44,45,46,47,48,49]. Although literature on the treatment of breast edema in specific is scarce, we recommend to extrapolate the CDT, which is thoroughly described for the extremities, for breast edema as well, to the utmost extent. CDT is currently the consensus treatment for lymphedema and consists of 4 main pillars: skin care, MLD, compression (bandaging and/or compressions garments) and exercise. The CDT is divided into 2 phases. The goal of phase 1, the intensive phase, is to reduce the swelling. The 4 components of phase 1 are skin care, MLD, compression using bandaging and exercise. Phase 2 aims at preserving the results of phase 1. It contains the same components as in phase 1, except for compression which is generally provided by compression garments instead of bandages. What follows is a synopsis of the 4 pillars of the CDT, and if applicable its evidence for breast edema.

The purpose of skin care is to maintain a healthy skin barrier. Damaged and dry skin can become an entry point for infection. Therefore, good skin hygiene, precautionary measures and wound prevention can reduce the risk of infection and possible worsening of the breast edema. Patients are instructed to wash the skin daily with neutral soaps, dry the skin thoroughly with attention for the inframammary fold and to use low pH lotions and emollients. In addition, patients are recommended to take precautionary measures. Besides skin hygiene, recommendations supported by scientific evidence for lymphedema in general are as follows: avoid trauma, disinfect and treat wounds immediately, avoid sauna visits and seek medical help in case of skin changes [42]. Additional information given to the patients can be relevant as well since they were proven to be risk factors for aggravating lymphedema. Therefore, these recommendations rely on common sense: maintain or achieve a healthy/normal BMI, protect the skin from sunburn and wear appropriate clothing and bra [42]. For breast edema in specific, risk factors are investigated in a systematic review of the literature [35]. Table 3 gives an overview of the risk factors found in literature, however consensus among studies is lacking. Also, those risk factors are not likely to be reversible by actions of the patients.

Table 3 Risk factors for breast edema

MLD is another pillar of the CDT which can be performed both in the intensive and maintenance phase. MLD is a massage technique that aims to promote the movement of lymphatic fluid out of the swollen area as well as the uptake of interstitial fluid by the lymphatic system [50]. Although MLD is a well-established treatment modality for lymphedema of the extremities in clinical practice, its effectiveness is still questioned among researchers [43,44,45,46,47,48,49]. For breast edema, scientific research concerning MLD is missing, although it is often administered in clinical practice. Lymph fluid from the breast is drained proximally towards the axillary and supraclavicular lymph nodes and/or towards the lymph nodes of the contralateral side. Evidence needs to be established in order to determine whether MLD should be omitted definitively from the CDT for breast edema or not. Nevertheless, currently, awaiting evidence concerning the role of MLD, it is our recommendation to exclude MLD from the breast edema treatment, as it is time consuming en costly.

During the intensive phase of the CDT, compression (see pictures, Fig. 3) is used in order to decrease the lymphedema volume for which most commonly, short-stretch multilayer bandages are used [50]. However, for breast edema it is difficult to apply the bandages correctly and with appropriate pressure and many women find it uncomfortable to wear. Therefore, a compression bra or sports bra of compression type can be provided instead. During the maintenance phase, the use of this type of bra can be continued. Importantly, scientific evidence concerning compression therapy for women with breast edema is scarce. A study of Johansson et al. investigated the treatment of breast edema using a sports bra of compression type with firm pressure flattening the breasts and compared it with ordinary bras [32]. This type of compression needed to be worn during daytime for 9 months. Results showed that this breast compression treatment had no effect on symptoms of breast edema and on the amount of local tissue water measured by the TDC. Therefore, the recommendation is to wear a sports bra of compression type, only if it doesn’t cause a negative impact on comfort. Additionally, closely monitor the symptoms of breast edema in order to intervene if necessary. It is needless to say that more research concerning this topic is of great importance.

Fig. 3

Overview of compression therapy for breast edema. During edema reduction therapy short stretch bandages as well as 2-layer self-adhesive compression systems can be used. During the maintenance phase, a sports bra or custom made compression bra can be used. The sports bra is sometimes used as preventative therapy as well, currently strong evidence of the preventative effect is lacking

It has consistently been demonstrated that exercise is beneficial for managing lymphedema, as well aerobic exercise as resistance training. However, only 1 study investigated whether women with breast edema would respond similarly to exercise than to those with arm edema [51]. This study investigated a supervised 12-week combined aerobic and resistance training program. The exercise group reported a greater reduction in breast-related symptoms than the control group, assessed by the EORTC BR23 breast symptom questions. Measures of extracellular fluid, assessed with bioimpedance spectroscopy ratio, decreased in the exercise group compared to the control group. No significant difference was detected in dermal thickness in the breast, assessed by ultrasound [51]. Improving the use of a muscle pump will stimulate the lymphatic transport and improving the overall physical endurance and strength will lead to a better physical condition and coping [42]. Importantly, strenuous exercise will not aggravate the lymphedema which is often falsely assumed [51, 52]. Therefore, they should not be avoided unless they provoke pain or articular problems.

Follow-up assessments

During the follow-up of a patient treated for breast edema, several assessments can be performed to determine treatment results. First, the BrEQ can be used. If during the treatment the BrEQ-score decreases to a value below the cut-off point of 8.5 this signifies a good result. Additionally, part 2 of the BrEQ can be used to monitor the impact of breast edema on quality of life and activities of daily living [34]. Of course a clinical examination can be performed periodically, especially to determine whether or not the pitting sign has disappeared completely. If pitting is absent, breast edema has been reduced. A more technical assessment that can be performed is the assessment of TDC. TDC ratios have been demonstrated as prognostic in the presence of edema [32, 53, 54]. In patients with bilateral edema, no TDC ratios can be calculated. For these patients the progression in TDC- value (a percentage of water) can be monitored.

Clinical implications

Breast edema can be a serious complaint which cannot be neglected. Etiologies for breast edema are versatile, which makes an accurate diagnosis of the underlying condition important. In case of breast edema after BCS and radiotherapy, it is recommended that all patients who receive this type of breast cancer treatment at least get informed about this forgotten complaint. In case of breast edema of another etiology, it is mandatory to rule out malignancies or other treatable causes.

In addition, similarities between breast edema and radiodermatitis can be observed, like for example edema, redness, hardness and pain [55]. It is not always possible to distinguish between both conditions. Breast edema, however, can be present prior to radiotherapy. We advise patients and health care workers to monitor breast complaints closely, and to intervene if necessary. To aid in the detection and monitoring of breast edema, we suggest to use the BrEQ in combination with a physical examination. This method is fast and doesn’t require much material or resources.

Breast edema follows a natural course in which we see a spontaneous decline in the months after radiotherapy. Furthermore, breast edema is often subclinical and therefore not recognized and acknowledged by health care workers, because breast complaints are mild. For those reasons, not all patients need treatment for breast edema. The take home message should be to closely monitor those patients in who the BrEQ-score doesn’t decline within 6 months after termination of radiotherapy and provide them with the appropriate therapy. We recommend a morbidity screening after breast cancer treatment on regular basis. Self-assessment using a checklist or smartphone application are both feasible approaches.

Since evidence concerning the treatment of breast edema is currently sparse, we recommend the CDT, by analogy with the lymphedema treatment of the extremities. However, we recommend omitting MLD, since its evidence is low. Therefore, the breast edema treatment involves skin care, exercise therapy and compression. Additionally, a patients should be informed about the normal course of breast edema development.

Take home messages:
- Patients should be informed about breast edema and its natural course.
- Patients treated with BCS and radiotherapy should be monitored till 12 months after the end of radiotherapy
- To aid in the detection and monitoring of breast edema, the use of the BrEQ in combination with a physical examination is a suitable approach.
- If no spontaneous decline of breast edema after 6 months is seen and no other treatable cause is found; start treating the edema
- Currently, CDT, with the exception of MLD, is the recommended treatment which involves skin care, compression and exercise therapy. However, strong scientific evidence still needs to be established.

Future research priorities

Long term prospective research is vital to gain better insight in breast edema as a morbidity after BCS and radiotherapy. Especially, since some patients still suffer from breast edema years after surgery. A longitudinal study could make it possible to detect when problems arise and could therefore be valuable to determine when appropriate treatment or sufficient information should be provided.

An international consensus should be reached among clinicians and researchers concerning the definition of breast edema. Furthermore, we need to consider a standardized assessment tool which could serve as a gold standard. The BrEQ could be considered as a gold standard since it covers all the domains of disability according to the ICF framework ( This Dutch questionnaire is the first to specifically assess breast edema. A translation (currently a Spanish, Turkish and English version are being prepared) and a further investigation of the degree to which the items on a translated BrEQ adequately reflect the items on the original Dutch version, is mandatory. Moreover, it is important to encourage researchers to consistently report whenever a modified version of the BrEQ is used.

Concerning the treatment of breast edema, high quality studies are necessary to prove the effectiveness of the CDT for breast edema in specific. Furthermore, the appropriate timing and specific content of the treatment program need to be further investigated. There could be a rationale for other treatment modalities like for example fascia release techniques, however, evidence for breast edema is currently lacking. Additionally, more attention and more scientific research should go to the treatment of skin complaints (including scar tissue treatment if necessary) and the importance of compression and exercise therapy.


Breast edema is a common complaint after BCS and radiotherapy, however little described in scientific literature. Sufficient information concerning the diagnosis, longitudinal course and treatment of breast edema should reach health care workers involved in breast cancer treatment in order to improve care for these patients.

Availability of data and materials

The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.



Breast conserving surgery


Breast edema questionnaire


Complex decongestive therapy


International Classification of Functioning, Disability and Health


Manual lymphatic drainage


Tissue dielectric constant


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All authors contributed to the study conception and design. Data collection and analysis were performed by Hanne Verbelen and Nick Gebruers. The first draft of the manuscript was written by Hanne Verbelen en Nick Gebruers. All authors (Hanne Verbelen, Nick Gebruers, Dorien Dombrecht and Wiebren Tjalma) commented on previous versions of the manuscript and read and approved the final manuscript.

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Correspondence to Nick Gebruers.

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Supplementary Information

Additional file 1.

Breast edema questionnaire (BrEQ) – English version. Note: The English translation of the BreQ has not yet been validated.

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Verbelen, H., Tjalma, W., Dombrecht, D. et al. Breast edema, from diagnosis to treatment: state of the art. Arch Physiother 11, 8 (2021).

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  • Breast neoplasms
  • Breast edema
  • Diagnosis
  • Management